Severe COPD
Lung surgery
This involves lung volume reduction surgery. Severe COPD patients that remain breathless and have severe restrictions on activities of daily living even though they are on maximum therapy (including pulmonary rehabilitation) should be considered for this. They need to meet all of the following:
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FEV1 > 20% predicted
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PaCO2 < 7.3kPa
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Upper lobe predominant emphysema
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A carbon monoxide transfer factor (TLCO) > 20% predicted
Lung transplantation
Patients with severe COPD who remain breathless and have severe restrictions on activities of daily living even though they are on maximum therapy should be considered for this. Other factors that should be considered include:
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Co-morbidities
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Age
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FEV1
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PaCO2
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Homogeneously distributed emphysema (shown on a CT scan)
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Elevated pulmonary artery pressures with progressive deterioration
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Local surgical protocols
Palliative Care
Defined by the World Health Organisation (WHO) as:
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“An approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems including physical, psychosocial and spiritual issues.”
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The accessibility of these services is often less for COPD patients than cancer patients. Alleviation of symptoms such as anxiety, depression, cough, dry mouth. Viscous secretions, fatigue and dyspnoea should be a priority in palliative care of COPD patients. These patients should be able to access the range of services offered by palliative care multidisciplinary teams, including access to hospices.
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Opioids can be used to treat dyspnoea in end-stage COPD which has been unresponsive to other treatments. A Cochrane review showed that oral and parenteral opioids are both effective, however, nebulised opioids had no effect. In many COPD patients opioids have shown to reduce breathlessness by around 20%. Other possible treatments include the use of benzodiazepines, tricyclic antidepressants and oxygen.
Bibliography
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CPPE – Chronic Obstructive Pulmonary Disease Book 1
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https://www.nice.org.uk/guidance/CG101/chapter/1-Guidance#managing-stable-copd